Amyloid Precursor Protein and Tau Peptides Linked Together Ameliorate Loss of Cognition in an Alzheimer’s Disease Animal Model

The major proteins involved in Alzheimer’s disease (AD) are amyloid precursor protein (APP) and Tau. We demonstrate that APP1 (390–412) and Tau1 (19–34), linked together with either a flexible or a rigid peptide bridge, are able to inhibit, in vitro, the interaction between APP and Tau proteins. Fur...

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Detalles Bibliográficos
Autores principales: Maron, Ruth, Vinik, Yaron, Tsoory, Michael, Wilchek, Meir, Arnon, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420176/
https://www.ncbi.nlm.nih.gov/pubmed/37569901
http://dx.doi.org/10.3390/ijms241512527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420176/
https://www.ncbi.nlm.nih.gov/pubmed/37569901
http://dx.doi.org/10.3390/ijms241512527

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