Inhibitor Design Strategy for Myostatin: Dynamics and Interaction Networks Define the Affinity and Release Mechanisms of the Inhibited Complexes

Myostatin, an important negative regulator of muscle mass, is a therapeutic target for muscle atrophic disorders such as muscular dystrophy. Thus, the inhibition of myostatin presents a strategy to treat these disorders. It has long been established that the myostatin prodomain is a strong inhibitor...

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Detalles Bibliográficos
Autores principales: Nagy-Fazekas, Dóra, Fazekas, Zsolt, Taricska, Nóra, Stráner, Pál, Karancsiné Menyhárd, Dóra, Perczel, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420283/
https://www.ncbi.nlm.nih.gov/pubmed/37570625
http://dx.doi.org/10.3390/molecules28155655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420283/
https://www.ncbi.nlm.nih.gov/pubmed/37570625
http://dx.doi.org/10.3390/molecules28155655

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