Computational Investigation of Mechanisms for pH Modulation of Human Chloride Channels

Many transmembrane proteins are modulated by intracellular or extracellular pH. Investigation of pH dependence generally proceeds by mutagenesis of a wide set of amino acids, guided by properties such as amino-acid conservation and structure. Prediction of pKas can streamline this process, allowing...

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Detalles Bibliográficos
Autores principales: Elverson, Kathleen, Freeman, Sally, Manson, Forbes, Warwicker, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420675/
https://www.ncbi.nlm.nih.gov/pubmed/37570721
http://dx.doi.org/10.3390/molecules28155753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420675/
https://www.ncbi.nlm.nih.gov/pubmed/37570721
http://dx.doi.org/10.3390/molecules28155753

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