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Systematic Analysis of Covalent and Allosteric Protein Kinase Inhibitors

In drug discovery, protein kinase inhibitors (PKIs) are intensely investigated as drug candidates in different therapeutic areas. While ATP site-directed, non-covalent PKIs have long been a focal point in protein kinase (PK) drug discovery, in recent years, there has been increasing interest in allo...

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Detalles Bibliográficos
Autores principales: Xerxa, Elena, Laufkötter, Oliver, Bajorath, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10420927/
https://www.ncbi.nlm.nih.gov/pubmed/37570774
http://dx.doi.org/10.3390/molecules28155805