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Mediation of BMI on 25-Hydroxyvitamin D Levels in U.S. Adults with Sugar-Sweetened Beverages Consumption

Body mass index (BMI) as well as sugar-sweetened beverages (SSB) has been suggested to independently decrease 25-hydroxyvitamin D (25(OH)D). However, the relationship between SSB, BMI, and 25(OH)D is uncertain. This study aimed to investigate the potential mediating role of BMI in the association be...

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Autores principales: Lin, Wei-Ting, Gonzalez, Gabrielle V., Kao, Yu-Hsiang, Lin, Hui-Yi, Li, Mirandy S., Seal, David W., Lee, Chien-Hung, Hu, Chih-yang, Chen, Lei-Shih, Tseng, Tung-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421177/
https://www.ncbi.nlm.nih.gov/pubmed/37571227
http://dx.doi.org/10.3390/nu15153291
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author Lin, Wei-Ting
Gonzalez, Gabrielle V.
Kao, Yu-Hsiang
Lin, Hui-Yi
Li, Mirandy S.
Seal, David W.
Lee, Chien-Hung
Hu, Chih-yang
Chen, Lei-Shih
Tseng, Tung-Sung
author_facet Lin, Wei-Ting
Gonzalez, Gabrielle V.
Kao, Yu-Hsiang
Lin, Hui-Yi
Li, Mirandy S.
Seal, David W.
Lee, Chien-Hung
Hu, Chih-yang
Chen, Lei-Shih
Tseng, Tung-Sung
author_sort Lin, Wei-Ting
collection PubMed
description Body mass index (BMI) as well as sugar-sweetened beverages (SSB) has been suggested to independently decrease 25-hydroxyvitamin D (25(OH)D). However, the relationship between SSB, BMI, and 25(OH)D is uncertain. This study aimed to investigate the potential mediating role of BMI in the association between SSB intake and 25(OH)D. A total of 4505 representative U.S. adults aged above 20 years and without liver conditions were selected from the 2013–2014 NHANES. All analyses were performed under survey modules with appropriate sampling weights. The prevalence of 25(OH)D insufficiency and deficiency was 37.8% and 24.1% in U.S. adults, respectively. Compared with non-SSB consumers, an increased risk of vitamin D deficiency was found in either heavy SSB consumers or soda consumers, respectively (aOR = 2.10, 95% CI = 1.25–3.54 in heavy SSB consumers; aOR = 1.61, 95% CI = 1.06–2.44 in soda consumers). Around 21.3% of the total effect of sugar intake from SSB on decreased 25(OH)D was explained by BMI. In conclusion, high total sugar intake from SSB and BMI independently contribute to lower 25(OH)D, and BMI mediates the inverse association between total sugar intake from SSB intake and 25(OH)D. Furthermore, an increased risk of having vitamin D deficiency was found in the population who consumed higher levels of sugar from SSB or soda drinks.
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spelling pubmed-104211772023-08-12 Mediation of BMI on 25-Hydroxyvitamin D Levels in U.S. Adults with Sugar-Sweetened Beverages Consumption Lin, Wei-Ting Gonzalez, Gabrielle V. Kao, Yu-Hsiang Lin, Hui-Yi Li, Mirandy S. Seal, David W. Lee, Chien-Hung Hu, Chih-yang Chen, Lei-Shih Tseng, Tung-Sung Nutrients Article Body mass index (BMI) as well as sugar-sweetened beverages (SSB) has been suggested to independently decrease 25-hydroxyvitamin D (25(OH)D). However, the relationship between SSB, BMI, and 25(OH)D is uncertain. This study aimed to investigate the potential mediating role of BMI in the association between SSB intake and 25(OH)D. A total of 4505 representative U.S. adults aged above 20 years and without liver conditions were selected from the 2013–2014 NHANES. All analyses were performed under survey modules with appropriate sampling weights. The prevalence of 25(OH)D insufficiency and deficiency was 37.8% and 24.1% in U.S. adults, respectively. Compared with non-SSB consumers, an increased risk of vitamin D deficiency was found in either heavy SSB consumers or soda consumers, respectively (aOR = 2.10, 95% CI = 1.25–3.54 in heavy SSB consumers; aOR = 1.61, 95% CI = 1.06–2.44 in soda consumers). Around 21.3% of the total effect of sugar intake from SSB on decreased 25(OH)D was explained by BMI. In conclusion, high total sugar intake from SSB and BMI independently contribute to lower 25(OH)D, and BMI mediates the inverse association between total sugar intake from SSB intake and 25(OH)D. Furthermore, an increased risk of having vitamin D deficiency was found in the population who consumed higher levels of sugar from SSB or soda drinks. MDPI 2023-07-25 /pmc/articles/PMC10421177/ /pubmed/37571227 http://dx.doi.org/10.3390/nu15153291 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Wei-Ting
Gonzalez, Gabrielle V.
Kao, Yu-Hsiang
Lin, Hui-Yi
Li, Mirandy S.
Seal, David W.
Lee, Chien-Hung
Hu, Chih-yang
Chen, Lei-Shih
Tseng, Tung-Sung
Mediation of BMI on 25-Hydroxyvitamin D Levels in U.S. Adults with Sugar-Sweetened Beverages Consumption
title Mediation of BMI on 25-Hydroxyvitamin D Levels in U.S. Adults with Sugar-Sweetened Beverages Consumption
title_full Mediation of BMI on 25-Hydroxyvitamin D Levels in U.S. Adults with Sugar-Sweetened Beverages Consumption
title_fullStr Mediation of BMI on 25-Hydroxyvitamin D Levels in U.S. Adults with Sugar-Sweetened Beverages Consumption
title_full_unstemmed Mediation of BMI on 25-Hydroxyvitamin D Levels in U.S. Adults with Sugar-Sweetened Beverages Consumption
title_short Mediation of BMI on 25-Hydroxyvitamin D Levels in U.S. Adults with Sugar-Sweetened Beverages Consumption
title_sort mediation of bmi on 25-hydroxyvitamin d levels in u.s. adults with sugar-sweetened beverages consumption
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421177/
https://www.ncbi.nlm.nih.gov/pubmed/37571227
http://dx.doi.org/10.3390/nu15153291
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