A universal deep-learning model for zinc finger design enables transcription factor reprogramming

Cys(2)His(2) zinc finger (ZF) domains engineered to bind specific target sequences in the genome provide an effective strategy for programmable regulation of gene expression, with many potential therapeutic applications. However, the structurally intricate engagement of ZF domains with DNA has made...

Descripción completa

Detalles Bibliográficos
Autores principales: Ichikawa, David M., Abdin, Osama, Alerasool, Nader, Kogenaru, Manjunatha, Mueller, April L., Wen, Han, Giganti, David O., Goldberg, Gregory W., Adams, Samantha, Spencer, Jeffrey M., Razavi, Rozita, Nim, Satra, Zheng, Hong, Gionco, Courtney, Clark, Finnegan T., Strokach, Alexey, Hughes, Timothy R., Lionnet, Timothee, Taipale, Mikko, Kim, Philip M., Noyes, Marcus B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421740/
https://www.ncbi.nlm.nih.gov/pubmed/36702896
http://dx.doi.org/10.1038/s41587-022-01624-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421740/
https://www.ncbi.nlm.nih.gov/pubmed/36702896
http://dx.doi.org/10.1038/s41587-022-01624-4

Ejemplares similares