Cargando…

Fibroblast activation in response to TGFβ1 is modulated by co-culture with endothelial cells in a vascular organ-on-chip platform

Background: Tissue fibrosis is a major healthcare burden that affects various organs in the body for which no effective treatments exist. An underlying, emerging theme across organs and tissue types at early stages of fibrosis is the activation of pericytes and/or fibroblasts in the perivascular spa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luu, Rebeccah J., Hoefler, B. Christopher, Gard, Ashley L., Ritenour, Casey R., Rogers, Miles T., Kim, Ernest S., Coppeta, Jonathan R., Cain, Brian P., Isenberg, Brett C., Azizgolshani, Hesham, Fajardo-Ramirez, Oscar R., García-Cardeña, Guillermo, Lech, Matthew P., Tomlinson, Lindsay, Charest, Joseph L., Williams, Corin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421749/ https://www.ncbi.nlm.nih.gov/pubmed/37577751 http://dx.doi.org/10.3389/fmolb.2023.1160851

Ejemplares similares

Measurement of oxygen consumption rates of human renal proximal tubule cells in an array of organ-on-chip devices to monitor drug-induced metabolic shifts
por: Kann, Samuel H., et al.
Publicado: (2022)

A high-throughput, 28-day, microfluidic model of gingival tissue inflammation and recovery
por: Gard, Ashley L., et al.
Publicado: (2023)

A high-throughput microfluidic bilayer co-culture platform to study endothelial-pericyte interactions
por: Rogers, Miles T., et al.
Publicado: (2021)

Oncoimmunology Meets Organs-on-Chip
por: Mattei, Fabrizio, et al.
Publicado: (2021)

High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro
por: Gard, A. L., et al.
Publicado: (2021)

Endoplasmic Reticulum Associated Protein Degradation (ERAD) in the Pathology of Diseases Related to TGFβ Signaling Pathway: Future Therapeutic Perspectives
por: Gariballa, Nesrin, et al.
Publicado: (2020)

TGFβ signaling pathways in human health and disease
por: Chen, Pei-Yu, et al.
Publicado: (2023)

The Post-translational Modifications of Smurf2 in TGF-β Signaling
por: Bai, Yangjinming, et al.
Publicado: (2020)

Evaluation of rapid transepithelial electrical resistance (TEER) measurement as a metric of kidney toxicity in a high-throughput microfluidic culture system
por: Shaughnessey, Erin M., et al.
Publicado: (2022)

PIPE-chipSAD: A Pipeline for the Analysis of High Density Arrays of Bacterial Transcriptomes
por: Bottini, Silvia, et al.
Publicado: (2016)

The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
por: Zou, Ming-Li, et al.
Publicado: (2021)

Glycosylation-on-a-Chip: A Flow-Based Microfluidic System for Cell-Free Glycoprotein Biosynthesis
por: Aquino, Alicia K., et al.
Publicado: (2021)

Editorial: TGF-β signalling pathways and their enigmatic role as a friend and foe in human health and diseases
por: Betapudi, Venkaiah, et al.
Publicado: (2023)

Antrodia camphorata-Derived Antrodin C Inhibits Liver Fibrosis by Blocking TGF-Beta and PDGF Signaling Pathways
por: Xu, Xin-Yi, et al.
Publicado: (2022)

Depletion of ALMS1 affects TGF-β signalling pathway and downstream processes such as cell migration and adhesion capacity
por: Bea-Mascato, Brais, et al.
Publicado: (2022)

CCN2/CTGF tip the balance of growth factors towards TGF-β2 in primary open-angle glaucoma
por: Dillinger, Andrea E., et al.
Publicado: (2023)

Non-targeted Plasma Metabolome of Early and Late Lactation Gilts
por: Rempel, Lea A., et al.
Publicado: (2016)

Proteomic Profiling of Fallopian Tube-Derived Extracellular Vesicles Using a Microfluidic Tissue-on-Chip System
por: Zha, Didi, et al.
Publicado: (2023)

Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition
por: Zhou, Yilu, et al.
Publicado: (2021)

The Hepatoprotective Effect of Piperine Against Thioacetamide-Induced Liver Fibrosis in Mice: The Involvement of miR-17 and TGF-β/Smads Pathways
por: Abdelhamid, Amr M., et al.
Publicado: (2021)

Long non-coding RNA lncMGC mediates the expression of TGF-β-induced genes in renal cells via nucleosome remodelers
por: Kato, Mitsuo, et al.
Publicado: (2023)

A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro
por: Shoemaker, James T., et al.
Publicado: (2020)

LZerD Protein-Protein Docking Webserver Enhanced With de novo Structure Prediction
por: Christoffer, Charles, et al.
Publicado: (2021)

Mechanically Activated Calcium Channel PIEZO1 Modulates Radiation-Induced Epithelial-Mesenchymal Transition by Forming a Positive Feedback With TGF-β1
por: Huang, Jia-Qi, et al.
Publicado: (2021)

Pan-Cancer Analysis and Validation Reveals that D-Dimer-Related Genes are Prognostic and Downregulate CD8(+) T Cells via TGF-Beta Signaling in Gastric Cancer
por: Guan, Yiming, et al.
Publicado: (2022)

LINC00174 Facilitates Cell Proliferation, Cell Migration and Tumor Growth of Osteosarcoma via Regulating the TGF-β/SMAD Signaling Pathway and Upregulating SSH2 Expression
por: Zheng, Changjun, et al.
Publicado: (2021)

VASH-1 Regulates Oxidative Stress and Fibrosis in Diabetic Kidney Disease via SIRT1/HIF1α and TGFβ1/Smad3 Signaling Pathways
por: Ren, Huiwen, et al.
Publicado: (2020)

Retraction: LINC00174 facilitates cell proliferation, cell migration and tumor growth of osteosarcoma via regulating the TGF-β/SMAD signaling pathway and upregulating SSH2 expression
por: Frontiers Editorial Office,
Publicado: (2023)

Silencing of lncRNA MIR497HG via CRISPR/Cas13d Induces Bladder Cancer Progression Through Promoting the Crosstalk Between Hippo/Yap and TGF-β/Smad Signaling
por: Zhuang, Changshui, et al.
Publicado: (2020)

Corrigendum: Silencing of lncRNA MIR497HG via CRISPR/Cas13d Induces Bladder Cancer Progression Through Promoting the Crosstalk Between Hippo/Yap and TGF-β/Smad Signaling
por: Zhuang, Changshui, et al.
Publicado: (2021)

A platform to reproducibly evaluate human colon permeability and damage
por: Marr, Elizabeth E., et al.
Publicado: (2023)

A High-Throughput, High-Containment Human Primary Epithelial Airway Organ-on-Chip Platform for SARS-CoV-2 Therapeutic Screening
por: Fisher, Christine R., et al.
Publicado: (2023)

A New Subfamily of Glycoside Hydrolase Family 30 with Strict Xylobiohydrolase Function
por: Crooks, Casey, et al.
Publicado: (2021)

Concurrent Identification and Characterization of Protein Structure and Continuous Internal Dynamics with REDCRAFT
por: Omar, Hanin, et al.
Publicado: (2022)

Arginine anchor points govern H3 tail dynamics
por: Jennings, Christine E., et al.
Publicado: (2023)

Polyanion order controls liquid-to-solid phase transition in peptide/nucleic acid co-assembly
por: Gordon-Kim, Christella, et al.
Publicado: (2022)

Impact of Formulation Choices on the Freeze-Drying of an Interleukin-6 Reference Material
por: Matejtschuk, Paul, et al.
Publicado: (2022)

Recurrent Urinary Tract Infection: A Mystery in Search of Better Model Systems
por: Murray, Benjamin O., et al.
Publicado: (2021)

Boosting Natural Killer Cell Therapies in Glioblastoma Multiforme Using Supramolecular Cationic Inhibitors of Heat Shock Protein 90
por: Saha, Tanmoy, et al.
Publicado: (2021)

Increased Local Testosterone Levels Alter Human Fallopian Tube mRNA Profile and Signaling
por: Russo, Angela, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4s79skk1k1nfdtftvqv4tajq7t