Preclinical Considerations for Long-acting Delivery of Tenofovir Alafenamide from Subdermal Implants for HIV Pre-exposure Prophylaxis

PURPOSE: Long-acting formulations of the potent antiretroviral prodrug tenofovir alafenamide (TAF) hold potential as biomedical HIV prevention modalities. Here, we present a rigorous comparison of three animal models, C57BL/6 J mice, beagle dogs, and merino sheep for evaluating TAF implant pharmacok...

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Detalles Bibliográficos
Autores principales: Gunawardana, Manjula, Remedios-Chan, Mariana, Sanchez, Debbie, Fanter, Rob, Webster, Simon, Webster, Paul, Moss, John A., Trinh, MyMy, Beliveau, Martin, Ramirez, Christina M., Marzinke, Mark A., Kuo, Joseph, Gallay, Philippe A., Baum, Marc M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421770/
https://www.ncbi.nlm.nih.gov/pubmed/36418671
http://dx.doi.org/10.1007/s11095-022-03440-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421770/
https://www.ncbi.nlm.nih.gov/pubmed/36418671
http://dx.doi.org/10.1007/s11095-022-03440-6

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