Raman Spectroscopic Analysis of Highly-Concentrated Antibodies under the Acid-Treated Conditions

PURPOSE: Antibody drugs are usually formulated as highly-concentrated solutions, which would easily generate aggregates, resulting in loss of efficacy. Although low pH increases the colloidal dispersion of antibodies, acid denaturation can be an issue. Therefore, knowing the physical properties at l...

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Detalles Bibliográficos
Autores principales: Sato, Yusui, Nagatoishi, Satoru, Noguchi, Shintaro, Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421790/
https://www.ncbi.nlm.nih.gov/pubmed/37160850
http://dx.doi.org/10.1007/s11095-023-03526-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421790/
https://www.ncbi.nlm.nih.gov/pubmed/37160850
http://dx.doi.org/10.1007/s11095-023-03526-9

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