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Raman Spectroscopic Analysis of Highly-Concentrated Antibodies under the Acid-Treated Conditions
PURPOSE: Antibody drugs are usually formulated as highly-concentrated solutions, which would easily generate aggregates, resulting in loss of efficacy. Although low pH increases the colloidal dispersion of antibodies, acid denaturation can be an issue. Therefore, knowing the physical properties at l...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421790/ https://www.ncbi.nlm.nih.gov/pubmed/37160850 http://dx.doi.org/10.1007/s11095-023-03526-9 |