The acquisition order of leukemic drug resistance mutations is directed by the selective fitness associated with each resistance mechanism

In Chronic Myeloid Leukemia, the transition from drug sensitive to drug resistant disease is poorly understood. Here, we used exploratory sequencing of gene transcripts to determine the mechanisms of drug resistance in a dasatinib resistant cell line model. Importantly, cell samples were collected s...

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Detalles Bibliográficos
Autores principales: Leow, Benjamin C. S., Kok, Chung H., Yeung, David T., Hughes, Timothy P., White, Deborah L., Eadie, Laura N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421868/
https://www.ncbi.nlm.nih.gov/pubmed/37567965
http://dx.doi.org/10.1038/s41598-023-40279-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421868/
https://www.ncbi.nlm.nih.gov/pubmed/37567965
http://dx.doi.org/10.1038/s41598-023-40279-2

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