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The acquisition order of leukemic drug resistance mutations is directed by the selective fitness associated with each resistance mechanism
In Chronic Myeloid Leukemia, the transition from drug sensitive to drug resistant disease is poorly understood. Here, we used exploratory sequencing of gene transcripts to determine the mechanisms of drug resistance in a dasatinib resistant cell line model. Importantly, cell samples were collected s...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421868/ https://www.ncbi.nlm.nih.gov/pubmed/37567965 http://dx.doi.org/10.1038/s41598-023-40279-2 |