Rational design of PD-1-CD28 immunostimulatory fusion proteins for CAR T cell therapy

BACKGROUND: In many situations, the therapeutic efficacy of CAR T cells is limited due to immune suppression and poor persistence. Immunostimulatory fusion protein (IFP) constructs have been advanced as a tool to convert suppressive signals into stimulation and thus promote the persistence of T cell...

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Detalles Bibliográficos
Autores principales: Lorenzini, Theo, Cadilha, Bruno L., Obeck, Hannah, Benmebarek, Mohamed-Reda, Märkl, Florian, Michaelides, Stefanos, Strzalkowski, Thaddäus, Briukhovetska, Daria, Müller, Philipp Jie, Nandi, Sayantan, Winter, Pia, Majed, Lina, Grünmeier, Ruth, Seifert, Matthias, Rausch, Svenja, Feuchtinger, Tobias, Endres, Stefan, Kobold, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421897/
https://www.ncbi.nlm.nih.gov/pubmed/37400680
http://dx.doi.org/10.1038/s41416-023-02332-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421897/
https://www.ncbi.nlm.nih.gov/pubmed/37400680
http://dx.doi.org/10.1038/s41416-023-02332-9

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