Discovering metabolic vulnerability using spatially resolved metabolomics for antitumor small molecule-drug conjugates development as a precise cancer therapy strategy

Against tumor-dependent metabolic vulnerability is an attractive strategy for tumor-targeted therapy. However, metabolic inhibitors are limited by the drug resistance of cancerous cells due to their metabolic plasticity and heterogeneity. Herein, choline metabolism was discovered by spatially resolv...

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Detalles Bibliográficos
Autores principales: Wang, Xiangyi, Zhang, Jin, Zheng, Kailu, Du, Qianqian, Wang, Guocai, Huang, Jianpeng, Zhou, Yanhe, Li, Yan, Jin, Hongtao, He, Jiuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422108/
https://www.ncbi.nlm.nih.gov/pubmed/37577390
http://dx.doi.org/10.1016/j.jpha.2023.02.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422108/
https://www.ncbi.nlm.nih.gov/pubmed/37577390
http://dx.doi.org/10.1016/j.jpha.2023.02.010

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