HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin

Small molecules that bind to allosteric sites on target proteins to alter protein function are highly sought in drug discovery. High-throughput screening (HTS) assays are needed to facilitate the direct discovery of allosterically active compounds. We have developed technology for high-throughput ti...

Descripción completa

Detalles Bibliográficos
Autores principales: Muretta, JM, Rajasekaran, D, Blat, Y, Little, S, Myers, M, Nair, C, Burdekin, B, Yuen, SL, Jimenez, N, Guhathakurta, P, Wilson, A, Thompson, AR, Surti, N, Connors, D, Chase, P, Harden, D, Barbieri, CM, Adam, L, Thomas, DD
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422832/
https://www.ncbi.nlm.nih.gov/pubmed/37307989
http://dx.doi.org/10.1016/j.slasd.2023.06.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422832/
https://www.ncbi.nlm.nih.gov/pubmed/37307989
http://dx.doi.org/10.1016/j.slasd.2023.06.001

Ejemplares similares