Blockade of C5aR1 alleviates liver inflammation and fibrosis in a mouse model of NASH by regulating TLR4 signaling and macrophage polarization

BACKGROUND: Nonalcoholic steatohepatitis (NASH) is an advanced form of chronic fatty liver disease, which is a driver of hepatocellular carcinoma. However, the roles of the C5aR1 in the NASH remain poorly understood. Here, we aimed to investigate the functions and mechanisms of the C5aR1 on hepatic...

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Detalles Bibliográficos
Autores principales: Jiang, Keqing, Lu, Shibang, Li, Dongxiao, Liu, Mingjiang, Jin, Hu, Lei, Biao, Wang, Sifan, Long, Kang, He, Songqing, Zhong, Fudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Original Article―Liver, Pancreas, and Biliary Tract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423130/
https://www.ncbi.nlm.nih.gov/pubmed/37227481
http://dx.doi.org/10.1007/s00535-023-02002-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423130/
https://www.ncbi.nlm.nih.gov/pubmed/37227481
http://dx.doi.org/10.1007/s00535-023-02002-w

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