Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc

c-Myc, a transcription factor, induces cell proliferation and is often aberrantly or highly expressed in cancers. However, molecular mechanisms underlying this aberrantly high expression remain unclear. Here, we found that intracellular Ca(2+) concentration regulates c-Myc oncoprotein stability. We...

Descripción completa

Detalles Bibliográficos
Autores principales: Masaki, Takahiro, Habara, Makoto, Hanaki, Shunsuke, Sato, Yuki, Tomiyasu, Haruki, Miki, Yosei, Shimada, Midori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423207/
https://www.ncbi.nlm.nih.gov/pubmed/37573463
http://dx.doi.org/10.1038/s41598-023-40412-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423207/
https://www.ncbi.nlm.nih.gov/pubmed/37573463
http://dx.doi.org/10.1038/s41598-023-40412-1

Ejemplares similares