Co-inhibition of glutaminolysis and one-carbon metabolism promotes ROS accumulation leading to enhancement of chemotherapeutic efficacy in anaplastic thyroid cancer

Anaplastic thyroid cancer (ATC) is one of the most aggressive tumors with an extremely poor prognosis. Based on the several biological features related to glutamine metabolism in ATC, we hypothesized glutaminolysis inhibition induces cell death in ATC cells. However, glutamine metabolism inhibition...

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Detalles Bibliográficos
Autores principales: Hwang, Yeseong, Yun, Hyeok Jun, Jeong, Jae Woong, Kim, Minki, Joo, Seyeon, Lee, Hae-Kyung, Chang, Hang-Seok, Kim, Seok-Mo, Fang, Sungsoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423221/
https://www.ncbi.nlm.nih.gov/pubmed/37573361
http://dx.doi.org/10.1038/s41419-023-06041-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423221/
https://www.ncbi.nlm.nih.gov/pubmed/37573361
http://dx.doi.org/10.1038/s41419-023-06041-2

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