Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase

The dual functions of TMEM16F as Ca(2+)-activated ion channel and lipid scramblase raise intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA-approved drug niclosamide to inhibit TMEM16F-dependent syncytia formation induced by SARS-CoV-2, we examined cryo-EM stru...

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Detalles Bibliográficos
Autores principales: Feng, Shengjie, Puchades, Cristina, Ko, Juyeon, Wu, Hao, Chen, Yifei, Figueroa, Eric E., Gu, Shuo, Han, Tina W., Ho, Brandon, Cheng, Tong, Li, Junrui, Shoichet, Brian, Jan, Yuh Nung, Cheng, Yifan, Jan, Lily Yeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423226/
https://www.ncbi.nlm.nih.gov/pubmed/37573365
http://dx.doi.org/10.1038/s41467-023-40410-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423226/
https://www.ncbi.nlm.nih.gov/pubmed/37573365
http://dx.doi.org/10.1038/s41467-023-40410-x

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