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Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rate

Cancer somatic mutations are the product of multiple mutational and repair processes, some of which are tightly associated with DNA replication. Mutation rates (MR) are known to be higher in late replication timing (RT) regions, but different processes can affect this association. Systematic analysi...

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Detalles Bibliográficos
Autores principales: Vardi-Yaacov, Oriya, Yaacov, Adar, Rosenberg, Shai, Simon, Itamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423235/
https://www.ncbi.nlm.nih.gov/pubmed/37573368
http://dx.doi.org/10.1038/s41598-023-39463-1