Biosensor Guided Polyketide Synthases Engineering for Optimization of Domain Exchange Boundaries

Type I modular polyketide synthases (PKSs) are multi-domain enzymes functioning like assembly lines. Many engineering attempts have been made for the last three decades to replace, delete and insert new functional domains into PKSs to produce novel molecules. However, inserting heterologous domains...

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Detalles Bibliográficos
Autores principales: Englund, Elias, Schmidt, Matthias, Nava, Alberto A., Klass, Sarah, Keiser, Leah, Dan, Qingyun, Katz, Leonard, Yuzawa, Satoshi, Keasling, Jay D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423236/
https://www.ncbi.nlm.nih.gov/pubmed/37573440
http://dx.doi.org/10.1038/s41467-023-40464-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423236/
https://www.ncbi.nlm.nih.gov/pubmed/37573440
http://dx.doi.org/10.1038/s41467-023-40464-x

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