NHC-catalyzed enantioselective access to β-cyano carboxylic esters via in situ substrate alternation and release

A carbene-catalyzed asymmetric access to chiral β-cyano carboxylic esters is disclosed. The reaction proceeds between β,β-disubstituted enals and aromatic thiols involving enantioselective protonation of enal β-carbon. Two main factors contribute to the success of this reaction. One involves in situ...

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Detalles Bibliográficos
Autores principales: Wang, Qingyun, Wu, Shuquan, Zou, Juan, Liang, Xuyang, Mou, Chengli, Zheng, Pengcheng, Chi, Yonggui Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423276/
https://www.ncbi.nlm.nih.gov/pubmed/37573355
http://dx.doi.org/10.1038/s41467-023-40645-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423276/
https://www.ncbi.nlm.nih.gov/pubmed/37573355
http://dx.doi.org/10.1038/s41467-023-40645-8

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