Downregulation of DNA methylation enhances differentiation of THP-1 cells and induces M1 polarization of differentiated macrophages

DNA methylation is an epigenetic modification that regulates gene expression and plays an essential role in hematopoiesis. UHRF1 and DNMT1 are both crucial for regulating genome-wide maintenance of DNA methylation. Specifically, it is well known that hypermethylation is crucial characteristic of acu...

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Detalles Bibliográficos
Autores principales: Park, Junyoung, Luo, Yongyang, Park, Jin Woo, Kim, Song Hyun, Hong, Ye Joo, Lim, Younghyun, Seo, Young-Jin, Bae, Jeehyeon, Seo, Sang Beom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423279/
https://www.ncbi.nlm.nih.gov/pubmed/37573395
http://dx.doi.org/10.1038/s41598-023-40362-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423279/
https://www.ncbi.nlm.nih.gov/pubmed/37573395
http://dx.doi.org/10.1038/s41598-023-40362-8

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