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53bp1 mutation enhances brca1 and bard1 embryonic lethality in C. elegans
In mice, mutation of brca1 results in embryonic lethality, which is partially suppressed by 53bp1 mutation. In contrast, mutation of the C. elegans BRCA1 ortholog, brc-1 , or its binding partner, brd-1 , lead to only mild embryonic lethality. We show that in C. elegans , brc-1 and brd-1 embryonic le...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Caltech Library
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423319/ https://www.ncbi.nlm.nih.gov/pubmed/37581122 http://dx.doi.org/10.17912/micropub.biology.000934 |