Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade

OBJECTIVE: Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. DESIGN: Glutathione peroxidase 4 (GPx4), which is considered the master regulator of ferroptosis, was genetically altered in murine models for hepatocellular...

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Detalles Bibliográficos
Autores principales: Conche, Claire, Finkelmeier, Fabian, Pešić, Marina, Nicolas, Adele M, Böttger, Tim W, Kennel, Kilian B, Denk, Dominic, Ceteci, Fatih, Mohs, Kathleen, Engel, Esther, Canli, Özge, Dabiri, Yasamin, Peiffer, Kai-Henrik, Zeuzem, Stefan, Salinas, Gabriela, Longerich, Thomas, Yang, Huan, Greten, Florian R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423492/
https://www.ncbi.nlm.nih.gov/pubmed/36707233
http://dx.doi.org/10.1136/gutjnl-2022-327909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423492/
https://www.ncbi.nlm.nih.gov/pubmed/36707233
http://dx.doi.org/10.1136/gutjnl-2022-327909

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