Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target

OBJECTIVES: Chronic hepatitis B virus (HBV) infection is a leading cause of liver disease and hepatocellular carcinoma. A key feature of HBV replication is the synthesis of the covalently close circular (ccc)DNA, not targeted by current treatments and whose elimination would be crucial for viral cur...

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Detalles Bibliográficos
Autores principales: Verrier, Eloi R, Ligat, Gaëtan, Heydmann, Laura, Doernbrack, Katharina, Miller, Julija, Maglott-Roth, Anne, Jühling, Frank, El Saghire, Houssein, Heuschkel, Margaux J, Fujiwara, Naoto, Hsieh, Sen-Yung, Hoshida, Yujin, Root, David E, Felli, Emanuele, Pessaux, Patrick, Mukherji, Atish, Mailly, Laurent, Schuster, Catherine, Brino, Laurent, Nassal, Michael, Baumert, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423543/
https://www.ncbi.nlm.nih.gov/pubmed/36591611
http://dx.doi.org/10.1136/gutjnl-2020-323665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423543/
https://www.ncbi.nlm.nih.gov/pubmed/36591611
http://dx.doi.org/10.1136/gutjnl-2020-323665

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