Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure

Simonson et al. compare non-failing and ischemic cardiomyopathy human left ventricles using snRNA-seq and identify an increase in lymphatic and angiogenic endothelial cells in disease. Transcriptionally, ischemic cardiomyopathy is similar to other cardiomyopathies. Gene targets from this shared expr...

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Autores principales: Simonson, Bridget, Chaffin, Mark, Hill, Matthew C., Atwa, Ondine, Guedira, Yasmine, Bhasin, Harshit, Hall, Amelia W., Hayat, Sikander, Baumgart, Simon, Bedi, Kenneth C., Margulies, Kenneth B., Klattenhoff, Carla A., Ellinor, Patrick T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423750/
https://www.ncbi.nlm.nih.gov/pubmed/36790929
http://dx.doi.org/10.1016/j.celrep.2023.112086
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author Simonson, Bridget
Chaffin, Mark
Hill, Matthew C.
Atwa, Ondine
Guedira, Yasmine
Bhasin, Harshit
Hall, Amelia W.
Hayat, Sikander
Baumgart, Simon
Bedi, Kenneth C.
Margulies, Kenneth B.
Klattenhoff, Carla A.
Ellinor, Patrick T.
author_facet Simonson, Bridget
Chaffin, Mark
Hill, Matthew C.
Atwa, Ondine
Guedira, Yasmine
Bhasin, Harshit
Hall, Amelia W.
Hayat, Sikander
Baumgart, Simon
Bedi, Kenneth C.
Margulies, Kenneth B.
Klattenhoff, Carla A.
Ellinor, Patrick T.
author_sort Simonson, Bridget
collection PubMed
description Simonson et al. compare non-failing and ischemic cardiomyopathy human left ventricles using snRNA-seq and identify an increase in lymphatic and angiogenic endothelial cells in disease. Transcriptionally, ischemic cardiomyopathy is similar to other cardiomyopathies. Gene targets from this shared expression profile could be explored for therapeutic benefit in end-stage heart failure.
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spelling pubmed-104237502023-10-23 Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure Simonson, Bridget Chaffin, Mark Hill, Matthew C. Atwa, Ondine Guedira, Yasmine Bhasin, Harshit Hall, Amelia W. Hayat, Sikander Baumgart, Simon Bedi, Kenneth C. Margulies, Kenneth B. Klattenhoff, Carla A. Ellinor, Patrick T. Cell Rep Article Simonson et al. compare non-failing and ischemic cardiomyopathy human left ventricles using snRNA-seq and identify an increase in lymphatic and angiogenic endothelial cells in disease. Transcriptionally, ischemic cardiomyopathy is similar to other cardiomyopathies. Gene targets from this shared expression profile could be explored for therapeutic benefit in end-stage heart failure. 2023-02-28 2023-02-14 /pmc/articles/PMC10423750/ /pubmed/36790929 http://dx.doi.org/10.1016/j.celrep.2023.112086 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Simonson, Bridget
Chaffin, Mark
Hill, Matthew C.
Atwa, Ondine
Guedira, Yasmine
Bhasin, Harshit
Hall, Amelia W.
Hayat, Sikander
Baumgart, Simon
Bedi, Kenneth C.
Margulies, Kenneth B.
Klattenhoff, Carla A.
Ellinor, Patrick T.
Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure
title Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure
title_full Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure
title_fullStr Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure
title_full_unstemmed Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure
title_short Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure
title_sort single-nucleus rna sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423750/
https://www.ncbi.nlm.nih.gov/pubmed/36790929
http://dx.doi.org/10.1016/j.celrep.2023.112086
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