Cargando…

Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure

Simonson et al. compare non-failing and ischemic cardiomyopathy human left ventricles using snRNA-seq and identify an increase in lymphatic and angiogenic endothelial cells in disease. Transcriptionally, ischemic cardiomyopathy is similar to other cardiomyopathies. Gene targets from this shared expr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simonson, Bridget, Chaffin, Mark, Hill, Matthew C., Atwa, Ondine, Guedira, Yasmine, Bhasin, Harshit, Hall, Amelia W., Hayat, Sikander, Baumgart, Simon, Bedi, Kenneth C., Margulies, Kenneth B., Klattenhoff, Carla A., Ellinor, Patrick T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423750/ https://www.ncbi.nlm.nih.gov/pubmed/36790929 http://dx.doi.org/10.1016/j.celrep.2023.112086

Ejemplares similares

Assembly assay identifies a critical region of human fibrillin-1 required for 10–12 nm diameter microfibril biogenesis
por: Jensen, Sacha A., et al.
Publicado: (2021)

Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration
por: Nollet, Edgar E, et al.
Publicado: (2023)

Cardiomyocyte‐Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans
por: Sharifi‐Sanjani, Maryam, et al.
Publicado: (2017)

Transcriptional, Post-Transcriptional, and Post-Translational Mechanisms Rewrite the Tubulin Code During Cardiac Hypertrophy and Failure
por: Phyo, Sai Aung, et al.
Publicado: (2022)

Ranking models of transmembrane β-barrel proteins using Z-coordinate predictions
por: Hayat, Sikander, et al.
Publicado: (2012)

C-type natriuretic peptide co-ordinates cardiac structure and function
por: Moyes, Amie J, et al.
Publicado: (2020)

Pathogenesis of Cardiomyopathy Caused by Variants in ALPK3, an Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere
por: Agarwal, Radhika, et al.
Publicado: (2022)

Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy
por: Pirruccello, James P., et al.
Publicado: (2020)

Prediction of the burial status of transmembrane residues of helical membrane proteins
por: Park, Yungki, et al.
Publicado: (2007)

Evaluation of colorectal cancer subtypes and cell lines using deep learning
por: Ronen, Jonathan, et al.
Publicado: (2019)

Aberrant DNA Polymerase Beta Enhances H. pylori Infection Induced Genomic Instability and Gastric Carcinogenesis in Mice
por: Zhao, Shengyuan, et al.
Publicado: (2019)

Biological Control Potential of Two Steinernematid Species Against the Date Fruit Stalk Borer (Oryctes elegans Prell, Coleoptera: Scarabaeidae)
por: Atwa, Atwa A
Publicado: (2018)

Differential Regulation of PDE5 Expression in Left and Right Ventricles of Feline Hypertrophy Models
por: Shan, Xiaoyin, et al.
Publicado: (2011)

Emerging Tools for Computer-Aided Diagnosis and Prognostication
por: Ritter, Scott, et al.
Publicado: (2014)

Mesopontine rostromedial tegmental nucleus neurons projecting to the dorsal raphe and pedunculopontine tegmental nucleus: psychostimulant-elicited Fos expression and collateralization
por: Lavezzi, Heather N., et al.
Publicado: (2011)

Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease
por: Dukinfield, Matthew, et al.
Publicado: (2019)

Characteristics, reasons and patterns of Road Traffic Injuries presenting in emergency department of a tertiary care public hospital in Karachi
por: Muhammad, Khaista, et al.
Publicado: (2022)

Bovine Model of Doxorubicin-Induced Cardiomyopathy
por: Bartoli, Carlo R., et al.
Publicado: (2011)

Mutation in DNA Polymerase Beta Causes Spontaneous Chromosomal Instability and Inflammation-Associated Carcinogenesis in Mice
por: Zhao, Shengyuan, et al.
Publicado: (2019)

Hybrid Mathematical Model of Cardiomyocyte Turnover in the Adult Human Heart
por: Elser, Jeremy A., et al.
Publicado: (2012)

Is it Time for Trials on Preventing Immune-Mediated Myocardial Damage?
por: Peyster, Eliot G., et al.
Publicado: (2021)

Tissue Rings PLOD Out a Second Hit in Becker Muscular Dystrophy
por: Lee, Benjamin W., et al.
Publicado: (2023)

New Cardiotoxicity Risk Assessment Guidelines: Searching for Validation
por: Rashed, Eman R., et al.
Publicado: (2023)

Microtubule-independent movement of the fission yeast nucleus
por: Ashraf, Sanju, et al.
Publicado: (2021)

Nucleus-nucleus collision as superposition of nucleon-nucleus collisions
por: Orlova, G I, et al.
Publicado: (1999)

Hard probes in nucleus-nucleus collisions
por: Lourenco, C.
Publicado: (1996)

Conference on the Structure of the Nucleus at the Dawn of the Century : Nucleus-Nucleus Collisions
por: Bonsignori, Giovanni C, et al.
Publicado: (2001)

Myocarditis Leading to Severe Dilated Cardiomyopathy in a Patient with Dengue Fever
por: Tahir, Hassan, et al.
Publicado: (2015)

Intermediate mass dimuons in ultrarelativistic proton-nucleus and nucleus-nucleus collisions at the CERN-SPS
por: Soave, C
Publicado: (1998)

Lineage-specific regulatory changes in hypertrophic cardiomyopathy unraveled by single-nucleus RNA-seq and spatial transcriptomics
por: Liu, Xuanyu, et al.
Publicado: (2023)

Noncanonical WNT Activation in Human Right Ventricular Heart Failure
por: Edwards, Jonathan J., et al.
Publicado: (2020)

Fast model-free standardization and integration of single-cell transcriptomics data
por: Xu, Yang, et al.
Publicado: (2023)

MASI enables fast model-free standardization and integration of single-cell transcriptomics data
por: Xu, Yang, et al.
Publicado: (2023)

Current Perspectives on Nucleus Pulposus Fibrosis in Disc Degeneration and Repair
por: Sun, Yi, et al.
Publicado: (2022)

Memory effects in dissipative nucleus-nucleus collision
por: Yadav, H L, et al.
Publicado: (2002)

$J/\psi$ and $\psi$' suppression in nucleus-nucleus interactions
por: Lourenço, C
Publicado: (1995)

3rd International Conference on Nucleus-Nucleus Collisions
por: Détraz, C, et al.
Publicado: (1988)

Advanced Morphologic Analysis for Diagnosing Allograft Rejection: The Case of Cardiac Transplant Rejection
por: Peyster, Eliot G., et al.
Publicado: (2018)

How to Apply Translational Models to Probe Mechanisms of Cardiotoxicity
por: Livingston, Carissa E., et al.
Publicado: (2022)

Elucidating arrhythmogenic right ventricular cardiomyopathy with stem cells
por: Laurita, Kenneth R., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3o3bv5f4mi73g33c82bcvccerf