Synthesis of fluorinated triphenylphosphonium analogs that improve cancer cell selectivity and in vivo detection

Triphenylphosphonium (TPP(+)) compounds like mito-metformin (MMe) target cancer cells by exploiting their hyperpolarized mitochondrial membrane potential. Here, we present a protocol for synthesizing TPP(+) analogs with selectivity for mammalian cancer cells, reduced toxicity, and quantifiability us...

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Detalles Bibliográficos
Autores principales: Keyes, Robert F., McAllister, Donna, Dwinell, Michael B., Smith, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424135/
https://www.ncbi.nlm.nih.gov/pubmed/37552599
http://dx.doi.org/10.1016/j.xpro.2023.102437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424135/
https://www.ncbi.nlm.nih.gov/pubmed/37552599
http://dx.doi.org/10.1016/j.xpro.2023.102437

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