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Synthesis of fluorinated triphenylphosphonium analogs that improve cancer cell selectivity and in vivo detection
Triphenylphosphonium (TPP(+)) compounds like mito-metformin (MMe) target cancer cells by exploiting their hyperpolarized mitochondrial membrane potential. Here, we present a protocol for synthesizing TPP(+) analogs with selectivity for mammalian cancer cells, reduced toxicity, and quantifiability us...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424135/ https://www.ncbi.nlm.nih.gov/pubmed/37552599 http://dx.doi.org/10.1016/j.xpro.2023.102437 |