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Telomerase-targeted therapies in myeloid malignancies

Human telomeres are tandem arrays that are predominantly composed of 5′-TTAGGG-3′ nucleotide sequences at the terminal ends of chromosomes. These sequences serve 2 primary functions: they preserve genomic integrity by protecting the ends of chromosomes, preventing inappropriate degradation by DNA re...

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Detalles Bibliográficos
Autores principales: Waksal, Julian A., Bruedigam, Claudia, Komrokji, Rami S., Jamieson, Catriona H. M., Mascarenhas, John O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424149/
https://www.ncbi.nlm.nih.gov/pubmed/37216228
http://dx.doi.org/10.1182/bloodadvances.2023009903