User-friendly microfluidic system reveals native-like morphological and transcriptomic phenotypes induced by shear stress in proximal tubule epithelium

Drug-induced nephrotoxicity is a leading cause of drug attrition, partly due to the limited relevance of pre-clinical models of the proximal tubule. Culturing proximal tubule epithelial cells (PTECs) under fluid flow to mimic physiological shear stress has been shown to improve select phenotypes, bu...

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Detalles Bibliográficos
Autores principales: Khalil, Natalie N., Petersen, Andrew P., Song, Cheng J., Chen, Yibu, Takamoto, Kaelyn, Kellogg, Austin C., Chen, Elaine Zhelan, McMahon, Andrew P., McCain, Megan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424157/
https://www.ncbi.nlm.nih.gov/pubmed/37584027
http://dx.doi.org/10.1063/5.0143614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424157/
https://www.ncbi.nlm.nih.gov/pubmed/37584027
http://dx.doi.org/10.1063/5.0143614

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