Chamelogk: A Chromatographic Chameleonicity Quantifier to Design Orally Bioavailable Beyond-Rule-of-5 Drugs

[Image: see text] New chemical modalities in drug discovery include molecules belonging to the bRo5 chemical space. Because of their complex and flexible structure, bRo5 compounds often suffer from a poor solubility/permeability profile. Chameleonicity describes the capacity of a molecule to adapt t...

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Detalles Bibliográficos
Autores principales: Garcia Jimenez, Diego, Vallaro, Maura, Rossi Sebastiano, Matteo, Apprato, Giulia, D’Agostini, Giulia, Rossetti, Paolo, Ermondi, Giuseppe, Caron, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424176/
https://www.ncbi.nlm.nih.gov/pubmed/37490408
http://dx.doi.org/10.1021/acs.jmedchem.3c00823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424176/
https://www.ncbi.nlm.nih.gov/pubmed/37490408
http://dx.doi.org/10.1021/acs.jmedchem.3c00823

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