Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy

[Image: see text] Human African Trypanosomiasis (HAT), caused by Trypanosoma brucei, is one of the neglected tropical diseases with a continuing need for new medication. We here describe the discovery of 5-phenylpyrazolopyrimidinone analogs as a novel series of phenotypic antitrypanosomal agents. Th...

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Detalles Bibliográficos
Autores principales: Zheng, Yang, van den Kerkhof, Magali, van der Meer, Tiffany, Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, de Esch, Iwan J. P., Siderius, Marco, Matheeussen, An, Maes, Louis, Sterk, Geert Jan, Caljon, Guy, Leurs, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424178/
https://www.ncbi.nlm.nih.gov/pubmed/37471520
http://dx.doi.org/10.1021/acs.jmedchem.3c00161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424178/
https://www.ncbi.nlm.nih.gov/pubmed/37471520
http://dx.doi.org/10.1021/acs.jmedchem.3c00161

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