In Silico Discovery and Subsequent Characterization of Potent 4R-Tauopathy Positron Emission Tomography Radiotracers

[Image: see text] A chemical fingerprint search identified Z3777013540 (1-(5-(6-fluoro-1H-indol-2-yl)pyrimidin-2-yl)piperidin-4-ol; 1) as a potential 4R-tau binding ligand. Binding assays in post-mortem Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CB...

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Detalles Bibliográficos
Autores principales: Graham, Thomas J. A., Lindberg, Anton, Tong, Junchao, Stehouwer, Jeffrey S., Vasdev, Neil, Mach, Robert H., Mathis, Chester A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424182/
https://www.ncbi.nlm.nih.gov/pubmed/37487189
http://dx.doi.org/10.1021/acs.jmedchem.3c00775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424182/
https://www.ncbi.nlm.nih.gov/pubmed/37487189
http://dx.doi.org/10.1021/acs.jmedchem.3c00775

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