Ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression

BACKGROUND: Nicotinamide adenine dinucleotide (NAD+) is vital for not only energy metabolism but also signaling pathways. A major source of NAD+ depletion is the activation of poly (ADP-ribose) polymerase (PARP) in response to DNA damage. We have previously demonstrated that metformin can cause both...

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Detalles Bibliográficos
Autores principales: Zhuang, Yongxian, Haugrud, Allison B., Schaefer, Meg A., Messerli, Shanta M., Miskimins, W. Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424729/
https://www.ncbi.nlm.nih.gov/pubmed/37583931
http://dx.doi.org/10.3389/fonc.2023.1225220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424729/
https://www.ncbi.nlm.nih.gov/pubmed/37583931
http://dx.doi.org/10.3389/fonc.2023.1225220

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