Gelsevirine is a novel STING-specific inhibitor and mitigates STING-related inflammation in sepsis

BACKGROUND: Stimulation of IFN genes (STING) is central to the production of interferon and proinflammatory cytokines in response to microbial DNA or self-DNA in the cytosol. The detrimental role of the activation of STING during sepsis has been well documented. METHODS: Here, we found that gelsevir...

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Detalles Bibliográficos
Autores principales: Chen, Yuhong, Bian, Huihui, Lv, Juan, Song, Wanxue, Xing, Chunlei, Hui, Chunlei, Zhang, Dinglei, Zhang, Chenxi, Zhao, Liang, Li, Yingke, Su, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424845/
https://www.ncbi.nlm.nih.gov/pubmed/37583703
http://dx.doi.org/10.3389/fimmu.2023.1190707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424845/
https://www.ncbi.nlm.nih.gov/pubmed/37583703
http://dx.doi.org/10.3389/fimmu.2023.1190707

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