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Modelling host- Trypanosoma brucei gambiense interactions in vitro using human induced pluripotent stem cell-derived cortical brain organoids

Background: Sleeping sickness is caused by the extracellular parasite Trypanosoma brucei and is associated with neuroinflammation and neuropsychiatric disorders, including disruption of sleep/wake patterns, and is now recognised as a circadian disorder. Sleeping sickness is traditionally studied usi...

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Detalles Bibliográficos
Autores principales: Chandrasegaran, Praveena, Nabilla Lestari, Agatha, Sinton, Matthew C., Gopalakrishnan, Jay, Quintana, Juan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425695/
https://www.ncbi.nlm.nih.gov/pubmed/37588058
http://dx.doi.org/10.12688/f1000research.131507.2