Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes

PURPOSE: Deficiency in homologous recombination (HR) repair of DNA damage is characteristic of many high-grade serous ovarian cancers (HGSC). It is imperative to identify patients with homologous recombination–deficient (HRD) tumors as they are most likely to benefit from platinum-based chemotherapy...

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Detalles Bibliográficos
Autores principales: Pikkusaari, Sanna, Tumiati, Manuela, Virtanen, Anni, Oikkonen, Jaana, Li, Yilin, Perez-Villatoro, Fernando, Muranen, Taru, Salko, Matilda, Huhtinen, Kaisa, Kanerva, Anna, Koskela, Heidi, Tapper, Johanna, Koivisto-Korander, Riitta, Joutsiniemi, Titta, Haltia, Ulla-Maija, Lassus, Heini, Hautaniemi, Sampsa, Färkkilä, Anniina, Hynninen, Johanna, Hietanen, Sakari, Carpén, Olli, Kauppi, Liisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Precision Medicine and Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425726/
https://www.ncbi.nlm.nih.gov/pubmed/36805632
http://dx.doi.org/10.1158/1078-0432.CCR-22-3156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425726/
https://www.ncbi.nlm.nih.gov/pubmed/36805632
http://dx.doi.org/10.1158/1078-0432.CCR-22-3156

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