DNA-Methylome–Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy

PURPOSE: Tumor hypoxia is a paradigmatic negative prognosticator of treatment resistance in head and neck squamous cell carcinoma (HNSCC). The lack of robust and reliable hypoxia classifiers limits the adaptation of stratified therapies. We hypothesized that the tumor DNA methylation landscape might...

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Detalles Bibliográficos
Autores principales: Tawk, Bouchra, Rein, Katrin, Schwager, Christian, Knoll, Maximilian, Wirkner, Ute, Hörner-Rieber, Juliane, Liermann, Jakob, Kurth, Ina, Balermpas, Panagiotis, Rödel, Claus, Linge, Annett, Löck, Steffen, Lohaus, Fabian, Tinhofer, Ingeborg, Krause, Mechtild, Stuschke, Martin, Grosu, Anca Ligia, Zips, Daniel, Combs, Stephanie E., Belka, Claus, Stenzinger, Albrecht, Herold-Mende, Christel, Baumann, Michael, Schirmacher, Peter, Debus, Jürgen, Abdollahi, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Precision Medicine and Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425733/
https://www.ncbi.nlm.nih.gov/pubmed/37058257
http://dx.doi.org/10.1158/1078-0432.CCR-22-3790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425733/
https://www.ncbi.nlm.nih.gov/pubmed/37058257
http://dx.doi.org/10.1158/1078-0432.CCR-22-3790

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