Cargando…

Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication. RRM2 performs a critical role in th...

Descripción completa

Detalles Bibliográficos
Autores principales: Zuo, Zanwen, Zhou, Zerong, Chang, Yuzhou, Liu, Yan, Shen, Yuping, Li, Qizhang, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425756/
https://www.ncbi.nlm.nih.gov/pubmed/37588202
http://dx.doi.org/10.1016/j.gendis.2022.11.022
_version_ 1785089908030832640
author Zuo, Zanwen
Zhou, Zerong
Chang, Yuzhou
Liu, Yan
Shen, Yuping
Li, Qizhang
Zhang, Lei
author_facet Zuo, Zanwen
Zhou, Zerong
Chang, Yuzhou
Liu, Yan
Shen, Yuping
Li, Qizhang
Zhang, Lei
author_sort Zuo, Zanwen
collection PubMed
description Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication. RRM2 performs a critical role in the malignant biological behaviors of cancers. The structure, regulation, and function of RRM2 and its inhibitors were discussed. RRM2 gene can produce two transcripts encoding the same ORF. RRM2 expression is regulated at multiple levels during the processes from transcription to translation. Moreover, this gene is associated with resistance, regulated cell death, and tumor immunity. In order to develop and design inhibitors of RRM2, appropriate strategies can be adopted based on different mechanisms. Thus, a greater appreciation of the characteristics of RRM2 is a benefit for understanding tumorigenesis, resistance in cancer, and tumor microenvironment. Moreover, RRM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis.
format Online
Article
Text
id pubmed-10425756
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Chongqing Medical University
record_format MEDLINE/PubMed
spelling pubmed-104257562023-08-16 Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer Zuo, Zanwen Zhou, Zerong Chang, Yuzhou Liu, Yan Shen, Yuping Li, Qizhang Zhang, Lei Genes Dis Review Article Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication. RRM2 performs a critical role in the malignant biological behaviors of cancers. The structure, regulation, and function of RRM2 and its inhibitors were discussed. RRM2 gene can produce two transcripts encoding the same ORF. RRM2 expression is regulated at multiple levels during the processes from transcription to translation. Moreover, this gene is associated with resistance, regulated cell death, and tumor immunity. In order to develop and design inhibitors of RRM2, appropriate strategies can be adopted based on different mechanisms. Thus, a greater appreciation of the characteristics of RRM2 is a benefit for understanding tumorigenesis, resistance in cancer, and tumor microenvironment. Moreover, RRM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis. Chongqing Medical University 2022-12-28 /pmc/articles/PMC10425756/ /pubmed/37588202 http://dx.doi.org/10.1016/j.gendis.2022.11.022 Text en © 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Zuo, Zanwen
Zhou, Zerong
Chang, Yuzhou
Liu, Yan
Shen, Yuping
Li, Qizhang
Zhang, Lei
Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer
title Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer
title_full Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer
title_fullStr Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer
title_full_unstemmed Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer
title_short Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer
title_sort ribonucleotide reductase m2 (rrm2): regulation, function and targeting strategy in human cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425756/
https://www.ncbi.nlm.nih.gov/pubmed/37588202
http://dx.doi.org/10.1016/j.gendis.2022.11.022
work_keys_str_mv AT zuozanwen ribonucleotidereductasem2rrm2regulationfunctionandtargetingstrategyinhumancancer
AT zhouzerong ribonucleotidereductasem2rrm2regulationfunctionandtargetingstrategyinhumancancer
AT changyuzhou ribonucleotidereductasem2rrm2regulationfunctionandtargetingstrategyinhumancancer
AT liuyan ribonucleotidereductasem2rrm2regulationfunctionandtargetingstrategyinhumancancer
AT shenyuping ribonucleotidereductasem2rrm2regulationfunctionandtargetingstrategyinhumancancer
AT liqizhang ribonucleotidereductasem2rrm2regulationfunctionandtargetingstrategyinhumancancer
AT zhanglei ribonucleotidereductasem2rrm2regulationfunctionandtargetingstrategyinhumancancer