Cargando…

Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication. RRM2 performs a critical role in th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zuo, Zanwen, Zhou, Zerong, Chang, Yuzhou, Liu, Yan, Shen, Yuping, Li, Qizhang, Zhang, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Chongqing Medical University 2022
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425756/ https://www.ncbi.nlm.nih.gov/pubmed/37588202 http://dx.doi.org/10.1016/j.gendis.2022.11.022

Ejemplares similares

Sorafenib Inhibits Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in Hepatocellular Carcinoma Cells
por: Yang, Pei-Ming, et al.
Publicado: (2020)

The Clinical and Prognostic Significance of Ribonucleotide Reductase Subunits RRM1 and RRM2 mRNA Levels in Patients with Chronic Lymphocytic Leukemia
por: Chatzidavid, Sevastianos, et al.
Publicado: (2023)

Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)
por: Xia, Guanggai, et al.
Publicado: (2017)

Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients
por: Cho, Er-Chieh, et al.
Publicado: (2014)

Ribonucleotide reductase regulatory subunit M2 (RRM2) as a potential sero-diagnostic biomarker in non-small cell lung cancer
por: Zhou, Dandan, et al.
Publicado: (2023)

Regulation of ribonucleotide reductase M2 expression by the upstream AUGs
por: Dong, Zizheng, et al.
Publicado: (2005)

DHS (Trans-4,4’-Dihydroxystilbene) Suppresses DNA Replication and Tumor Growth by Inhibiting RRM2 (Ribonucleotide Reductase Regulatory Subunit M2)
por: Chen, Chi-Wei, et al.
Publicado: (2018)

Oxymatrine induces anti-tumor response in cervical cancer by modulating circ_0008460/miR-197-3p/ribonucleotide reductase subunit M2 (RRM2)
por: Li, Siwei, et al.
Publicado: (2022)

Ribonucleotide Reductase Subunit M2 Can Be New Molecular Target and Prognostic Biomarker of Hepatocellular Carcinoma
por: Kim, Hee Yeon, et al.
Publicado: (2014)

Ribonucleotide reductase, a novel drug target for gonorrhea
por: Narasimhan, Jana, et al.
Publicado: (2022)

Convergent allostery in ribonucleotide reductase
por: Thomas, William C., et al.
Publicado: (2019)

The periodic table of ribonucleotide reductases
por: Ruskoski, Terry B., et al.
Publicado: (2021)

Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present
por: Huff, Sarah E., et al.
Publicado: (2022)

Ribonucleotide reductase subunit M2 as a novel target for clear-cell renal cell carcinoma
por: Zou, Yun, et al.
Publicado: (2019)

The tyrosyl free radical in ribonucleotide reductase.
por: Gräslund, A, et al.
Publicado: (1985)

Human equilibrative nucleoside transporter-1 (hENT1) and ribonucleotide reductase regulatory subunit M1 (RRM1) expression; do they have survival impact to pancreatic cancer?
por: Hwang, Dae Wook, et al.
Publicado: (2020)

P53 suppresses ribonucleotide reductase via inhibiting mTORC1
por: He, Zhengfu, et al.
Publicado: (2017)

Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy
por: Wijerathna, Sanath R., et al.
Publicado: (2011)

Acetylation regulates ribonucleotide reductase activity and cancer cell growth
por: Chen, Guo, et al.
Publicado: (2019)

High Expression of Ribonucleotide Reductase Subunit M2 Correlates with Poor Prognosis of Hepatocellular Carcinoma
por: Lee, Boin, et al.
Publicado: (2014)

Ribonucleotide reductase small subunit M2 is a master driver of aggressive prostate cancer
por: Mazzu, Ying Z., et al.
Publicado: (2020)

Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle
por: Chen, Wan-Jing, et al.
Publicado: (2022)

Screening of traditional Chinese medicine monomers as ribonucleotide reductase M2 inhibitors for tumor treatment
por: Qin, Ya-Ya, et al.
Publicado: (2022)

Rational polynomial representation of ribonucleotide reductase activity
por: Radivoyevitch, Tomas, et al.
Publicado: (2005)

Ribonucleotide reductases: essential enzymes for bacterial life
por: Torrents, Eduard
Publicado: (2014)

Ribonucleotide Reductase Inhibitors: A New Look at an Old Target for Radiosensitization
por: Chapman, Tobias R., et al.
Publicado: (2012)

Methyl-Hydroxylamine as an Efficacious Antibacterial Agent That Targets the Ribonucleotide Reductase Enzyme
por: Julián, Esther, et al.
Publicado: (2015)

Antibody-assisted target identification reveals afatinib, an EGFR covalent inhibitor, down-regulating ribonucleotide reductase
por: Yu, Cheng-Han, et al.
Publicado: (2018)

Importance of the Maintenance Pathway in the Regulation of the Activity of Escherichia coli Ribonucleotide Reductase†
por: Hristova, Daniela, et al.
Publicado: (2008)

Ribonucleotide Reductases of Salmonella Typhimurium: Transcriptional Regulation and Differential Role in Pathogenesis
por: Panosa, Anaïs, et al.
Publicado: (2010)

Regulators of ribonucleotide reductase inhibit Ty1 mobility in saccharomyces cerevisiae
por: O'Donnell, John P, et al.
Publicado: (2010)

Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment
por: Bothou, Christina, et al.
Publicado: (2021)

The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity
por: Sluder, Isaac T., et al.
Publicado: (2018)

Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers
por: Zhang, Hang, et al.
Publicado: (2014)

A pan-cancer analysis of the oncogenic role of ribonucleotide reductase subunit M2 in human tumors
por: Li, Yaqun, et al.
Publicado: (2022)

Regulatory Role of Ribonucleotide Reductase Subunit M2 in Hepatocyte Growth and Pathogenesis of Hepatitis C Virus
por: Kitab, Bouchra, et al.
Publicado: (2023)

mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer()()
por: Tian, Ling, et al.
Publicado: (2021)

Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase
por: Liew, Li Phing, et al.
Publicado: (2016)

Structural determinants and distribution of phosphate specificity in ribonucleotide reductases
por: Schell, Eugen, et al.
Publicado: (2021)

Kinetic model for reversible radical transfer in ribonucleotide reductase
por: Reinhardt, Clorice R., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1re72kfsif2k6i0cjigplpvs00