CRISPR-Cas– induced IRF3 and MAVS knockouts in a salmonid cell line disrupt PRR signaling and affect viral replication

BACKGROUND: Interferon (IFN) responses are critical in the resolution of viral infections and are actively targeted by many viruses. They also play a role in inducing protective responses after vaccination and have been successfully tested as vaccine adjuvants. IFN responses are well conserved and f...

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Detalles Bibliográficos
Autores principales: van der Wal, Yorick A., Nordli, Henriette, Akandwanaho, Allan, Greiner-Tollersrud, Linn, Kool, Jaap, Jørgensen, Jorunn B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425769/
https://www.ncbi.nlm.nih.gov/pubmed/37588594
http://dx.doi.org/10.3389/fimmu.2023.1214912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425769/
https://www.ncbi.nlm.nih.gov/pubmed/37588594
http://dx.doi.org/10.3389/fimmu.2023.1214912

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