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Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either through β-catenin in the ca...

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Autores principales: Qin, Kevin, Yu, Michael, Fan, Jiaming, Wang, Hongwei, Zhao, Piao, Zhao, Guozhi, Zeng, Wei, Chen, Connie, Wang, Yonghui, Wang, Annie, Schwartz, Zander, Hong, Jeffrey, Song, Lily, Wagstaff, William, Haydon, Rex C., Luu, Hue H., Ho, Sherwin H., Strelzow, Jason, Reid, Russell R., He, Tong-Chuan, Shi, Lewis L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425814/
https://www.ncbi.nlm.nih.gov/pubmed/37588235
http://dx.doi.org/10.1016/j.gendis.2023.01.030
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author Qin, Kevin
Yu, Michael
Fan, Jiaming
Wang, Hongwei
Zhao, Piao
Zhao, Guozhi
Zeng, Wei
Chen, Connie
Wang, Yonghui
Wang, Annie
Schwartz, Zander
Hong, Jeffrey
Song, Lily
Wagstaff, William
Haydon, Rex C.
Luu, Hue H.
Ho, Sherwin H.
Strelzow, Jason
Reid, Russell R.
He, Tong-Chuan
Shi, Lewis L.
author_facet Qin, Kevin
Yu, Michael
Fan, Jiaming
Wang, Hongwei
Zhao, Piao
Zhao, Guozhi
Zeng, Wei
Chen, Connie
Wang, Yonghui
Wang, Annie
Schwartz, Zander
Hong, Jeffrey
Song, Lily
Wagstaff, William
Haydon, Rex C.
Luu, Hue H.
Ho, Sherwin H.
Strelzow, Jason
Reid, Russell R.
He, Tong-Chuan
Shi, Lewis L.
author_sort Qin, Kevin
collection PubMed
description Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either through β-catenin in the canonical pathway or through a series of other proteins in the noncanonical pathway. Many of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body, establishing the complex interplay between Wnt signaling and other signaling pathways. This crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ processes. Dysregulation of this system has been implicated in many diseases affecting a wide array of organ systems, including cancer and embryological defects, and can even cause embryonic lethality. The complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic treatments. However, both stimulatory and inhibitory treatments come with potential risks that need to be addressed. This review synthesized much of the current knowledge on the Wnt signaling pathway, beginning with the history of Wnt signaling. It thoroughly described the different variants of Wnt signaling, including canonical, noncanonical Wnt/PCP, and the noncanonical Wnt/Ca(2+) pathway. Further description involved each of its components and their involvement in other cellular processes. Finally, this review explained the various other pathways and processes that crosstalk with Wnt signaling.
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spelling pubmed-104258142023-08-16 Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk Qin, Kevin Yu, Michael Fan, Jiaming Wang, Hongwei Zhao, Piao Zhao, Guozhi Zeng, Wei Chen, Connie Wang, Yonghui Wang, Annie Schwartz, Zander Hong, Jeffrey Song, Lily Wagstaff, William Haydon, Rex C. Luu, Hue H. Ho, Sherwin H. Strelzow, Jason Reid, Russell R. He, Tong-Chuan Shi, Lewis L. Genes Dis Review Article Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either through β-catenin in the canonical pathway or through a series of other proteins in the noncanonical pathway. Many of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body, establishing the complex interplay between Wnt signaling and other signaling pathways. This crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ processes. Dysregulation of this system has been implicated in many diseases affecting a wide array of organ systems, including cancer and embryological defects, and can even cause embryonic lethality. The complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic treatments. However, both stimulatory and inhibitory treatments come with potential risks that need to be addressed. This review synthesized much of the current knowledge on the Wnt signaling pathway, beginning with the history of Wnt signaling. It thoroughly described the different variants of Wnt signaling, including canonical, noncanonical Wnt/PCP, and the noncanonical Wnt/Ca(2+) pathway. Further description involved each of its components and their involvement in other cellular processes. Finally, this review explained the various other pathways and processes that crosstalk with Wnt signaling. Chongqing Medical University 2023-03-24 /pmc/articles/PMC10425814/ /pubmed/37588235 http://dx.doi.org/10.1016/j.gendis.2023.01.030 Text en © 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Qin, Kevin
Yu, Michael
Fan, Jiaming
Wang, Hongwei
Zhao, Piao
Zhao, Guozhi
Zeng, Wei
Chen, Connie
Wang, Yonghui
Wang, Annie
Schwartz, Zander
Hong, Jeffrey
Song, Lily
Wagstaff, William
Haydon, Rex C.
Luu, Hue H.
Ho, Sherwin H.
Strelzow, Jason
Reid, Russell R.
He, Tong-Chuan
Shi, Lewis L.
Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk
title Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk
title_full Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk
title_fullStr Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk
title_full_unstemmed Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk
title_short Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk
title_sort canonical and noncanonical wnt signaling: multilayered mediators, signaling mechanisms and major signaling crosstalk
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425814/
https://www.ncbi.nlm.nih.gov/pubmed/37588235
http://dx.doi.org/10.1016/j.gendis.2023.01.030
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