Cryo‐EM structure of antibacterial efflux transporter QacA from Staphylococcus aureus reveals a novel extracellular loop with allosteric role

Efflux of antibacterial compounds is a major mechanism for developing antimicrobial resistance. In the Gram‐positive pathogen Staphylococcus aureus, QacA, a 14 transmembrane helix containing major facilitator superfamily antiporter, mediates proton‐coupled efflux of mono and divalent cationic antiba...

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Detalles Bibliográficos
Autores principales: Majumder, Puja, Ahmed, Shahbaz, Ahuja, Pragya, Athreya, Arunabh, Ranjan, Rakesh, Penmatsa, Aravind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425836/
https://www.ncbi.nlm.nih.gov/pubmed/37458117
http://dx.doi.org/10.15252/embj.2023113418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425836/
https://www.ncbi.nlm.nih.gov/pubmed/37458117
http://dx.doi.org/10.15252/embj.2023113418

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