PINE-TREE enables highly efficient genetic modification of human cell lines

Prime editing technologies enable precise genome editing without the caveats of CRISPR nuclease-based methods. Nonetheless, current approaches to identify and isolate prime-edited cell populations are inefficient. Here, we established a fluorescence-based system, prime-induced nucleotide engineering...

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Detalles Bibliográficos
Autores principales: Frisch, Carlye, Kostes, William W., Galyon, Brooke, Whitman, Brycelyn, Tekel, Stefan J., Standage-Beier, Kylie, Srinivasan, Gayathri, Wang, Xiao, Brafman, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425837/
https://www.ncbi.nlm.nih.gov/pubmed/37588683
http://dx.doi.org/10.1016/j.omtn.2023.07.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425837/
https://www.ncbi.nlm.nih.gov/pubmed/37588683
http://dx.doi.org/10.1016/j.omtn.2023.07.007

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