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Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing

Mitochondria are central regulators of healthspan and lifespan, yet the intricate choreography of multiple, tightly controlled steps regulating mitochondrial biogenesis remains poorly understood. Here, we uncover a pivotal role for specific elements of the 5′‐3′ mRNA degradation pathway in the regul...

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Detalles Bibliográficos
Autores principales: Daskalaki, Ioanna, Markaki, Maria, Gkikas, Ilias, Tavernarakis, Nektarios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425844/
https://www.ncbi.nlm.nih.gov/pubmed/37427543
http://dx.doi.org/10.15252/embj.2022112446