HDAC-6 inhibition ameliorates the early neuropathology in a mouse model of Krabbe disease

INTRODUCTION: In Krabbe disease (KD), mutations in β-galactosylceramidase (GALC), a lysosomal enzyme responsible for the catabolism of galactolipids, leads to the accumulation of its substrates galactocerebroside and psychosine. This neurologic condition is characterized by a severe and progressive...

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Detalles Bibliográficos
Autores principales: Braz, Sandra O., Morgado, Marlene M., Pereira, Marta I., Monteiro, Ana C., Golonzhka, Olga, Jarpe, Matthew, Brites, Pedro, Sousa, Monica M., Nogueira-Rodrigues, Joana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426153/
https://www.ncbi.nlm.nih.gov/pubmed/37588057
http://dx.doi.org/10.3389/fnmol.2023.1231659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426153/
https://www.ncbi.nlm.nih.gov/pubmed/37588057
http://dx.doi.org/10.3389/fnmol.2023.1231659

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