Cargando…

HDAC-6 inhibition ameliorates the early neuropathology in a mouse model of Krabbe disease

INTRODUCTION: In Krabbe disease (KD), mutations in β-galactosylceramidase (GALC), a lysosomal enzyme responsible for the catabolism of galactolipids, leads to the accumulation of its substrates galactocerebroside and psychosine. This neurologic condition is characterized by a severe and progressive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Braz, Sandra O., Morgado, Marlene M., Pereira, Marta I., Monteiro, Ana C., Golonzhka, Olga, Jarpe, Matthew, Brites, Pedro, Sousa, Monica M., Nogueira-Rodrigues, Joana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426153/ https://www.ncbi.nlm.nih.gov/pubmed/37588057 http://dx.doi.org/10.3389/fnmol.2023.1231659

Ejemplares similares

Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner
por: Brites, Pedro, et al.
Publicado: (2022)

Neuroimmune mechanisms in Krabbe's disease
por: Potter, Gregory B., et al.
Publicado: (2016)

Optic nerve enlargement in infantile form of Krabbe disease
por: Castilha-Neto, Dimas, et al.
Publicado: (2012)

Improved Brain Pathology and Progressive Peripheral Neuropathy in a 15 Year Old Survivor of Infantile Krabbe Disease Treated With Umbilical Cord Transplantation
por: Kofler, Julia, et al.
Publicado: (2022)

HDAC1 Regulates Neuronal Differentiation
por: Nieto-Estevez, Vanesa, et al.
Publicado: (2022)

Advances in the Diagnosis and Treatment of Krabbe Disease
por: Wenger, David A, et al.
Publicado: (2021)

Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2
por: Shearstone, Jeffrey R., et al.
Publicado: (2016)

Comprehensive Analysis of HDAC Family Identifies HDAC1 as a Prognostic and Immune Infiltration Indicator and HDAC1-Related Signature for Prognosis in Glioma
por: Fan, Yuxiang, et al.
Publicado: (2021)

Azasugar inhibitors as pharmacological chaperones for Krabbe disease
por: Hill, Chris H., et al.
Publicado: (2015)

Gene therapy for CNS diseases – Krabbe disease
por: Rafi, Mohammad A.
Publicado: (2016)

Krabbe disease: New hope for an old disease
por: Bradbury, Allison M., et al.
Publicado: (2021)

Krabbe disease: A personal perspective and hypothesis
por: Rafi, Mohammad A.
Publicado: (2022)

Neurodegenerative Disorder Risk in Krabbe Disease Carriers
por: Vantaggiato, Lorenza, et al.
Publicado: (2022)

The Effects of Antipsychotics in Experimental Models of Krabbe Disease
por: Sharma, Kapil, et al.
Publicado: (2023)

Globoid Cell Leukodystrophy (Krabbe Disease): An Update
por: Maghazachi, Azzam A
Publicado: (2023)

Cigarette Smoke Exposure Induces Neurocognitive Impairments and Neuropathological Changes in the Hippocampus
por: Dobric, Aleksandar, et al.
Publicado: (2022)

Adult Krabbe Disease That Was Successfully Treated with Intravenous Immunoglobulin
por: Fukazawa, Ryosuke, et al.
Publicado: (2020)

National U.S. Patient and Transplant Data for Krabbe Disease
por: Ghabash, Gabrielle, et al.
Publicado: (2021)

Efficacy and Safety of a Krabbe Disease Gene Therapy
por: Hordeaux, Juliette, et al.
Publicado: (2022)

Mechanotransduction Impairment in Primary Fibroblast Model of Krabbe Disease
por: Mezzena, Roberta, et al.
Publicado: (2023)

Galactosylceramidase deficiency and pathological abnormalities in cerebral white matter of Krabbe disease
por: Iacono, Diego, et al.
Publicado: (2022)

Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS
por: Tejido, Clara, et al.
Publicado: (2021)

FMRP-Driven Neuropathology in Autistic Spectrum Disorder and Alzheimer's disease: A Losing Game
por: Bleuzé, Louis, et al.
Publicado: (2021)

The Impact of Post-Analytical Tools on New York Screening for Krabbe Disease and Pompe Disease
por: Martin, Monica M., et al.
Publicado: (2020)

Molecular Mechanisms of Disease Pathogenesis Differ in Krabbe Disease Variants
por: Spratley, Samantha J., et al.
Publicado: (2016)

New therapeutic approaches for Krabbe disease: The potential of pharmacological chaperones
por: Spratley, Samantha J., et al.
Publicado: (2016)

Serendipitous effects of β-cyclodextrin on murine model of Krabbe disease
por: Katabuchi, Asaka U., et al.
Publicado: (2018)

Report of a Case that Expands the Phenotype of Infantile Krabbe Disease
por: Nashabat, Marwan, et al.
Publicado: (2019)

Genotype and phenotype classification of 29 patients affected by Krabbe disease
por: Madsen, Anna M. H., et al.
Publicado: (2019)

Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's Disease
por: Béchet, Sibylle, et al.
Publicado: (2020)

Chronic lithium administration in a mouse model for Krabbe disease
por: Del Grosso, Ambra, et al.
Publicado: (2021)

Krabbe Disease Associated With Mitochondrial Dysfunction in a Chinese Family
por: Wu, Liwen, et al.
Publicado: (2021)

Antisense Oligonucleotide-Mediated Reduction of HDAC6 Does Not Reduce Tau Pathology in P301S Tau Transgenic Mice
por: Valencia, Antonio, et al.
Publicado: (2021)

Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment
por: Ma, Jiacheng, et al.
Publicado: (2018)

Neuropathology of central nervous system involvement in TTR amyloidosis
por: Taipa, Ricardo, et al.
Publicado: (2022)

Krabbe Disease: Report of a Rare Lipid Storage and Neurodegenerative Disorder
por: Pavuluri, Pratyusha, et al.
Publicado: (2017)

Predominant Corticospinal Tract Involvement in a Late Infant with Krabbe Disease
por: Yoshimura, Ayumi, et al.
Publicado: (2016)

Consensus guidelines for newborn screening, diagnosis and treatment of infantile Krabbe disease
por: Kwon, Jennifer M., et al.
Publicado: (2018)

Quantification of 3D Brain Microangioarchitectures in an Animal Model of Krabbe Disease
por: Righi, Marco, et al.
Publicado: (2019)

Psychosine enhances the shedding of membrane microvesicles: Implications in demyelination in Krabbe’s disease
por: D’Auria, Ludovic, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_fpgqvsh6sg2lt2442bp8fmmcpv