Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury

BACKGROUND: Cerebral ischemia-reperfusion injury (CIRI) is the main cause leading to high mortality and neurological disability in patients with cardiac arrest/cardiopulmonary resuscitation (CA/CPR). Our previous study found that extracellular signal-regulated kinase (ERK) activation, dynamin-relate...

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Detalles Bibliográficos
Autores principales: Yuan, Zhang-Li, Mo, Yan-Zi, Li, De-Li, Xie, Lu, Chen, Meng-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426156/
https://www.ncbi.nlm.nih.gov/pubmed/37580749
http://dx.doi.org/10.1186/s12964-023-01211-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426156/
https://www.ncbi.nlm.nih.gov/pubmed/37580749
http://dx.doi.org/10.1186/s12964-023-01211-3

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